Cyclin E, a redundant cyclin in breast cancer
نویسندگان
چکیده
منابع مشابه
Redundant cyclin overexpression and gene amplification in breast cancer cells.
Cyclins are prime cell cycle regulators and are central to the control of major check points in eukaryotic cells. The aberrant expressions of two cyclins (i.e., cyclins A and D1) have been observed in some cancers, suggesting they may be involved in loss of growth control. However, in spite of these occasional changes involving only two cyclins, there are no clear connections between general de...
متن کاملCyclin A and cyclin E as prognostic factors in early breast cancer
This thesis is based on the following papers, which are referred to in the text by their Roman numerals. Reliability of cyclin A assessment on tissue microarrays in breast cancer compared to conventional histological slides.67 and cyclin A as prognostic factors in early breast cancer. Which is the optimal cutoff value? Histopathol-Is cyclin A a prognostic factor in node negative breast cancer? ...
متن کاملCyclin E, a potential prognostic marker for breast cancer.
A fundamental cause of cancer is changed properties of genetic material, which may deregulate normal development of the tissue or provide selective growth advantage to the tumor cell. This deregulation of cell proliferation results from altered production of a handful of proteins that play key roles in progression through the eukaryotic cell cycle. Some of these proteins include tumor suppresso...
متن کاملCyclin E Expression and Proliferation in Breast Cancer
Cyclin E is a part of the cell cycle machinery and aberrantly expressed in several malignancies including breast cancer. Since cyclin E is cell cycle specifically expressed, we wanted to examine the relation between proliferation and expression of cyclin E with special attention to tumours with overexpression of the protein. Seventy-four breast tumours were analysed for the expression of cyclin...
متن کاملThe Prognostic Value and Overexpression of Cyclin A Is Correlated with Gene Amplification of both Cyclin A and Cyclin E in Breast Cancer Patient
UNLABELLED Deregulation of cell cycle control is a hallmark of cancer. The primary cyclins (A, B1, D1, D3 and E) are crucial for cell cycle progression. Secondary cyclins (C and H) have putative indirect effects on cell cycle propulsion and are not previously evaluated in breast cancer. We have examined protein expression and gene amplification of cyclins in breast carcinomas and correlated the...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1996
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.93.26.15215